Iwe unoshanda mumunda we biomedical research?Kana zvakadaro, saka unogona kunge wakanzwa nezveSulfo-NHS.Sezvo basa rakakosha remukomboni uyu mukutsvaga richiramba richizivikanwa, komisheni iyi iri kupinda mumarabhoritari akawanda pasi rose.Muchinyorwa chino, tinokurukura kuti Sulfo-NHS chii uye nei chiri chishandiso chakakosha kune avo vanodzidza biological sainzi.
Kutanga, chii chinonzi Sulfo-NHS?Zita racho rinenge rakareba, saka ngatiritsemure.Sulfo inomirira sulfonic acid uye NHS inomirira N-hydroxysuccinimide.Kana aya macompound maviri asangana,Sulfo-NHSinogadzirwa.Mushonga uyu une mashandisiro akati wandei mukutsvagisa biomedical, asi chimwe chezvakakosha zvivakwa kugona kusarudza mapuroteni.
Sulfo-NHS inoshanda nekuita nema primary amines (kureva -NH2 mapoka) pamacheni eparutivi ezvisaririra zvelysine mumapuroteni.Chaizvoizvo, Sulfo-NHS inosanganisa "tag" mapuroteni, zvichiita kuti zvive nyore kuziva uye kuongorora mumhando dzakasiyana dzekuyedza.Izvi zvakakonzera kuti nzvimbo dzakawanda dzekutsvaga dzikwanise kufambira mberi nekururama kukuru uye nepamusoro-soro yehuwandu.
Saka, chii chinonzi Sulfo-NHS chinoshandiswa?Kumwe kushandiswa kwakajairwa kwekomputa iyi kuri mukutsvaga kweimmunology.Sulfo-NHS yakaratidzwa kunyatso nyora masoja ekudzivirira chirwere uye maantigen, achivhura nzira nyowani dzekudzidza nezve immune system kusagadzikana uye zvirwere.Uyezve,Sulfo-NHSinogona kushandiswa muzvidzidzo zveprotein-protein interaction sezvo ichibvumira vatsvakurudzi kuti vaone nekukurumidza uye nyore nyore apo mapuroteni maviri akabatana.
Imwe nzvimbo iyo Sulfo-NHS inoshandiswa zvakanyanya ndeye yeproteomics.Proteomics inodzidza chimiro uye kushanda kwese mapuroteni mumunhu, uyeSulfo-NHSchinhu chakakosha pakuongorora uku.Nekuisa mapuroteni neSulfo-NHS, vaongorori vanogona kuita ongororo kuti vawane ruzivo rwakadzama nezveproteome yechipenyu yakapihwa, iyo inogona kubatsira kuona zvingangoita biomarker yechirwere.
Sulfo-NHS inoitawo basa mukugadzirwa kwemishonga mitsva.Kana vaongorori vari kuyedza kugadzira mushonga mutsva, zvakakosha kuve nechokwadi kuti unonangana neprotein inodiwa uye kwete chero imwe puroteni iri mumuviri.NokushandisaSulfo-NHSkusarudza mapuroteni, vatsvakurudzi vanogona kuona zvinangwa zvemishonga inogona kubatsira kukurumidza kugadzirwa kwezvinodhaka.
Saka hezvo unayo!Sulfo-NHS inogona kunge isiri izwi rinonyatsozivikanwa kunze kwenharaunda yesainzi, asi komisheni iyi iri kukurumidza kuita chishandiso chakakosha mukutsvaga kwebiomedical.Kubva pakutsvagisa immunology kuenda kuproteomics kusvika pakuvandudza zvinodhaka, Sulfo-NHS iri kubatsira vaongorori kuita budiriro huru munzvimbo idzi uye isu tinofara kuona kuti ndezvipi zvakawanikwa zvinotevera.
Nguva yekutumira: Jun-12-2023